AFCI recommends the use of Stanhexidine® for skin preparation prior to needle insertion. It is recommended to first wash your hands, then swab all the areas where you intend to insert needles, whether or not they are intra-articular insertions, allowing the prep to dry for 30 seconds prior to inserting the needles.


  1. Do not mistakenly purchase the 450 mL or 4 L bottle of Stanhexidine® 2% Chlorhexidine V/V 4% isopropyl alcohol, as it is intended for scrubbing skin, not prepping for injection. It is red, sticky and messy and is intended to be mixed with water. The skin prepping type, which is called Stanhexidine 2% Aqueous (450 mL), is the type that AFCI recommends. Unfortunately, the manufacturer does not sell large bottles of this type.
  2. You can use Betadine if you prefer; Stanhexidine® is more user-friendly and does not have to be removed with alcohol after treatment, so it is practical to use for all points.

Click here for the full article on Stanhexadine written by Dr. Linda Rapson.


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